Genetics Genetic Predictors of Fibrin D-Dimer Levels in Healthy Adults

نویسندگان

  • Nicholas L. Smith
  • Jennifer E. Huffman
  • David P. Strachan
  • Jie Huang
  • Abbas Dehghan
  • Lorna M. Lopez
  • So-Youn Shin
  • Jens Baumert
  • Joshua C. Bis
  • Sarah H. Wild
  • Andre G. Uitterlinden
  • Angela M. Carter
  • Ozren Polašek
  • Alicja R. Rudnicka
  • Ming-Huei Chen
  • Sarah E. Harris
  • David C. Liewald
  • Alan J. Gow
  • Albert Tenesa
  • Eline Slagboom
  • Igor Rudan
  • Wendy L. McArdle
  • Bruce M. Psaty
  • Ian J. Deary
  • Nicole Soranzo
چکیده

Nicholas L. Smith, PhD*; Jennifer E. Huffman, MSc*; David P. Strachan, MD*; Jie Huang, MD, MPH*; Abbas Dehghan, MD, PhD*; Stella Trompet, PhD*; Lorna M. Lopez, PhD*; So-Youn Shin, PhD*; Jens Baumert, PhD*; Veronique Vitart, PhD; Joshua C. Bis, PhD; Sarah H. Wild, MD, PhD; Ann Rumley, PhD; Qiong Yang, PhD; Andre G. Uitterlinden, PhD; David. J. Stott, MD, PhD; Gail Davies, PhD; Angela M. Carter, PhD; Barbara Thorand, PhD, MPH; Ozren Polašek, MD, PhD; Barbara McKnight, PhD; Harry Campbell, MD; Alicja R. Rudnicka, PhD; Ming-Huei Chen, PhD; Brendan M. Buckley, PhD; Sarah E. Harris, PhD; Annette Peters, PhD; Drazen Pulanic, MD, PhD; Thomas Lumley, PhD; Anton J.M. de Craen, PhD; David C. Liewald, BSc; Christian Gieger, PhD; Susan Campbell, HND; Ian Ford, PhD; Alan J. Gow, PhD; Michelle Luciano, PhD; David J. Porteous, PhD; Xiuqing Guo, PhD; Naveed Sattar, MD, PhD; Albert Tenesa, PhD; Mary Cushman, MSc, MD; P. Eline Slagboom, PhD; Peter M. Visscher, PhD; Tim D. Spector, MD; Thomas Illig, PhD; Igor Rudan, MD, PhD; Edwin G. Bovill, MD; Alan F. Wright, PhD; Wendy L. McArdle, PhD; Geoffrey Tofler, PhD; Albert Hofman, MD, PhD; Rudi G.J. Westendorp, MD, PhD; John M. Starr, MD; Peter J. Grant, MD; Mahir Karakas, MD; Nicholas D. Hastie, PhD; Bruce M. Psaty, MD, PhD†; James F. Wilson, DPhil; Gordon D.O. Lowe, MD†; Christopher J. O’Donnell, MD, MPH†; Jacqueline C.M. Witteman, PhD†; J. Wouter Jukema, MD, PhD†; Ian J. Deary, PhD†; Nicole Soranzo, PhD†; Wolfgang Koenig, MD†; Caroline Hayward, PhD†

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Preanalytical, Analytical, and Postanalytical Variables on D-dimer Measurement

D-dimer is a soluble fibrin degradation product deriving from the plasmin-mediated degradation of cross-linked fibrin. D-dimer can hence be considered a biomarker of activation of coagulation and fibrinolysis, and it is routinely used for ruling out venous thromboembolism (VTE). D-dimer is increasingly used to assess the risk of VTE recurrence and to help define the uoptimal duration of anticoa...

متن کامل

Genetic predictors of fibrin D-dimer levels in healthy adults.

BACKGROUND Fibrin fragment D-dimer, one of several peptides produced when crosslinked fibrin is degraded by plasmin, is the most widely used clinical marker of activated blood coagulation. To identity genetic loci influencing D-dimer levels, we performed the first large-scale, genome-wide association search. METHODS AND RESULTS A genome-wide investigation of the genomic correlates of plasma D...

متن کامل

Plasma Fibrinogen and D-dimer in Children With Sepsis: A Single-center Experience

Background & Objectives:  In sepsis, enhanced fibrin formation, impaired fibrin degradation, and intravascular fibrin deposition lead to a prothrombotic state. The current study aimed at measuring various coagulation parameters to predict an early marker for disseminated intravascular coagulation (DIC). Methods: The current prospective s...

متن کامل

The value of D-Dimer as a biomarker in assessing disease severity and mortality in patients with Covid-19, a review study

The Covid-19 pandemic created by the 2019 Coronavirus-nCov has become one of the biggest health problems of the current century. Because this disease is new in human society and has no previous history, so our information about it is incomplete, and researchers are trying to study with extensive clinical studies and changes in the human body caused by the function of this virus. It is clear tha...

متن کامل

تاثیر دوازده هفته تمرینات ورزشی ترکیبی (قدرتی، استقامتی، پیلاتس و PNF) بر سطوح فیبرین دی دایمر (FDD) و اینترلوکین-6 در بیماران زن مبتلا به مولتیپل اسکلروزیس با درجات مختلف ناتوانی

Background and Objective:  Multiple Sclerosis (MS) is a neurological disorder that can restrict individual's ability to carry on their activities. The[J1]  aim of this study was to examine the effects of combined exercise training on serum Fibrin D-Dimer (FDD) and interleukin-6 in female multiple sclerosis patients with different levels of disability. Materials and Methods: 96 female patients ...

متن کامل

Diagnostic implication of fibrin degradation products and D-dimer in aortic dissection

Fibrin degradation products (FDP) and D-dimer have been considered to be involved in many vascular diseases. In this study we aimed to explore the diagnostic implication of FDP and D-dimer in aortic dissection patients. 202 aortic dissection patients were collected as the case group, 150 patients with other cardiovascular diseases, including myocardial infarction (MI, n = 45), pulmonary infarct...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011